INTRODUCING THE PUBLISHED INTERNATIONAL PAPER
<p style="text-align:center"><span style="font-size:130%"><strong>ADRENOCEPTORS AND SCD1 IN ADIPOCYTES/ADIPOSE TISSUES: THE EXPRESSION AND VARIATION IN HEALTH AND OBESITY</strong></span></p>
<p style="text-align:center"><span style="font-size:130%"><a href="https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=Chu+DT&cauthor_id=36631196">Dinh-Toi Chu</a><a href="https://pubmed.ncbi.nlm.nih.gov/36631196/#full-view-affiliation-1" title="Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam. Electronic address: chudinhtoi.hnue@mail.com."><sup>1</sup></a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=Bui+NL&cauthor_id=36631196">Nhat-Le Bui</a><a href="https://pubmed.ncbi.nlm.nih.gov/36631196/#full-view-affiliation-2" title="Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam."><sup>2</sup></a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=Le+NH&cauthor_id=36631196">Ngoc Hoan Le</a><a href="https://pubmed.ncbi.nlm.nih.gov/36631196/#full-view-affiliation-3" title="Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam."><sup>3</sup></a></span></p>
<p><span style="font-size:130%"><sup>1</sup>Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam</span></p>
<p><span style="font-size:130%"><sup>2</sup>Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam</span></p>
<p><span style="font-size:130%"><sup>3</sup>Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam</span></p>
<p> </p>
<p style="text-align:justify"><span style="font-size:130%"><strong>Abstract. </strong>Obesity, considered a metabolic disorder, is one of the most significant health issues that the community has to cope with today. A rising number of studies have been conducted to find out promising genetic targets for obese treatment. The sympathetic nervous system was proven to possess remarkable roles in energy metabolism, including the stimulation of lipolysis as well as thermogenesis, via distinct adrenoceptors appearing on the membrane of adipocyte. A decrease of β-adrenoceptor expression has been observed in obese individuals, which is related to reducing energy expenditure and developing obesity. While that the deficiency of stearoyl-CoA desaturase-1 (SCD1), which is a promising target for treatments of metabolic diseases, decreases oxidation and promotes the synthesis of fatty acids. Here, we emphasized several differences between distinct adrenoceptor subtypes, including their mRNA expression level and function in white adipose tissue and brown adipose tissue. We also highlighted SCD1's roles related to the progression of adipocytes and its changing expression under the obese condition in both rodents and humans, and furthermore, tried to figure out the interaction between adrenoceptors and SCD1 in adipose tissue.</span></p>
The article was published in the Journal "Prog Mol Biol Transl Sci" (IF = 3.622, Web of Science Group)
Original paper: 10.1016/bs.pmbts.2022.06.024
